The effects of pregnancy on the mouse thymic epithelium.
Identifieur interne : 004260 ( Main/Exploration ); précédent : 004259; suivant : 004261The effects of pregnancy on the mouse thymic epithelium.
Auteurs : A G Clarke [Royaume-Uni] ; A L Gil ; M D KendallSource :
- Cell and tissue research [ 0302-766X ] ; 1994.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux, Antigènes de différenciation des lymphocytes T (métabolisme), Facteur thymique sérique (métabolisme), Facteurs temps, Femelle, Gestation animale (immunologie), Grossesse, Immunohistochimie, Souris, Thymus (glande) (anatomie et histologie), Thymus (glande) (immunologie), Thymus (glande) (métabolisme), Épithélium (anatomie et histologie), Épithélium (immunologie), Épithélium (métabolisme).
- MESH :
- anatomie et histologie : Thymus (glande), Épithélium.
- immunologie : Gestation animale, Thymus (glande), Épithélium.
- métabolisme : Antigènes de différenciation des lymphocytes T, Facteur thymique sérique, Thymus (glande), Épithélium.
- Animaux, Anticorps monoclonaux, Facteurs temps, Femelle, Grossesse, Immunohistochimie, Souris.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal, Antigens, Differentiation, T-Lymphocyte (metabolism), Epithelium (anatomy & histology), Epithelium (immunology), Epithelium (metabolism), Female, Immunohistochemistry, Mice, Pregnancy, Pregnancy, Animal (immunology), Thymic Factor, Circulating (metabolism), Thymus Gland (anatomy & histology), Thymus Gland (immunology), Thymus Gland (metabolism), Time Factors.
- MESH :
- chemical , metabolism : Antigens, Differentiation, T-Lymphocyte, Thymic Factor, Circulating.
- chemical : Antibodies, Monoclonal.
- anatomy & histology : Epithelium, Thymus Gland.
- immunology : Epithelium, Pregnancy, Animal, Thymus Gland.
- metabolism : Epithelium, Thymus Gland.
- Animals, Female, Immunohistochemistry, Mice, Pregnancy, Time Factors.
Abstract
Changes in the murine thymus during pregnancy were studied using immunocytochemistry with monoclonal antibodies against thymic epithelial, neuroendocrine, and thymulin-producing cells, fibroblasts, blood vessels and connective tissue components. Extensive alterations occur in mid-pregnancy. The medulla was greatly enlarged in the involuted thymus, and there were greater numbers of epithelial cells. These epithelial cells had an altered distribution forming large structures surrounding spherical masses of mononuclear cells, lacked epithelial cells and often contained a central blood vessel with fibroblasts and connective tissue. We have called these structures 'medullary epithelial rings' (MERs). To our knowledge these structures have not been described before. Late in pregnancy the loss of the central mononuclear cells leaves collapsed structures in a smaller medulla that nevertheless retains many epithelial cells. In virgins and early-pregnancy, there are cortical channels free of epithelial cells that are very infrequent later in pregnancy. This may reflect the loss of steroid-sensitive thymocytes from the cortex. The influence of sex-steroids, neurological impulses and immune activity in causing the changes are discussed, as are the possible consequences in pregnancy of a reduced, thymocyte-depleted cortex and an enlarged medulla that shows great complexity and activity.
DOI: 10.1007/bf00319429
PubMed: 8111839
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002893
- to stream PubMed, to step Curation: 002893
- to stream PubMed, to step Checkpoint: 002708
- to stream Ncbi, to step Merge: 002967
- to stream Ncbi, to step Curation: 002967
- to stream Ncbi, to step Checkpoint: 002967
- to stream Main, to step Merge: 004322
- to stream Main, to step Curation: 004260
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The effects of pregnancy on the mouse thymic epithelium.</title>
<author><name sortKey="Clarke, A G" sort="Clarke, A G" uniqKey="Clarke A" first="A G" last="Clarke">A G Clarke</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Obstetrics and Gynaecology, Queen's Medical Centre, University of Nottingham, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Obstetrics and Gynaecology, Queen's Medical Centre, University of Nottingham</wicri:regionArea>
<placeName><settlement type="city">Nottingham</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Nottinghamshire</region>
</placeName>
<orgName type="university">Université de Nottingham</orgName>
</affiliation>
</author>
<author><name sortKey="Gil, A L" sort="Gil, A L" uniqKey="Gil A" first="A L" last="Gil">A L Gil</name>
</author>
<author><name sortKey="Kendall, M D" sort="Kendall, M D" uniqKey="Kendall M" first="M D" last="Kendall">M D Kendall</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1994">1994</date>
<idno type="RBID">pubmed:8111839</idno>
<idno type="pmid">8111839</idno>
<idno type="doi">10.1007/bf00319429</idno>
<idno type="wicri:Area/PubMed/Corpus">002893</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002893</idno>
<idno type="wicri:Area/PubMed/Curation">002893</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002893</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002708</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002708</idno>
<idno type="wicri:Area/Ncbi/Merge">002967</idno>
<idno type="wicri:Area/Ncbi/Curation">002967</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002967</idno>
<idno type="wicri:doubleKey">0302-766X:1994:Clarke A:the:effects:of</idno>
<idno type="wicri:Area/Main/Merge">004322</idno>
<idno type="wicri:Area/Main/Curation">004260</idno>
<idno type="wicri:Area/Main/Exploration">004260</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">The effects of pregnancy on the mouse thymic epithelium.</title>
<author><name sortKey="Clarke, A G" sort="Clarke, A G" uniqKey="Clarke A" first="A G" last="Clarke">A G Clarke</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Obstetrics and Gynaecology, Queen's Medical Centre, University of Nottingham, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Obstetrics and Gynaecology, Queen's Medical Centre, University of Nottingham</wicri:regionArea>
<placeName><settlement type="city">Nottingham</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Nottinghamshire</region>
</placeName>
<orgName type="university">Université de Nottingham</orgName>
</affiliation>
</author>
<author><name sortKey="Gil, A L" sort="Gil, A L" uniqKey="Gil A" first="A L" last="Gil">A L Gil</name>
</author>
<author><name sortKey="Kendall, M D" sort="Kendall, M D" uniqKey="Kendall M" first="M D" last="Kendall">M D Kendall</name>
</author>
</analytic>
<series><title level="j">Cell and tissue research</title>
<idno type="ISSN">0302-766X</idno>
<imprint><date when="1994" type="published">1994</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Monoclonal</term>
<term>Antigens, Differentiation, T-Lymphocyte (metabolism)</term>
<term>Epithelium (anatomy & histology)</term>
<term>Epithelium (immunology)</term>
<term>Epithelium (metabolism)</term>
<term>Female</term>
<term>Immunohistochemistry</term>
<term>Mice</term>
<term>Pregnancy</term>
<term>Pregnancy, Animal (immunology)</term>
<term>Thymic Factor, Circulating (metabolism)</term>
<term>Thymus Gland (anatomy & histology)</term>
<term>Thymus Gland (immunology)</term>
<term>Thymus Gland (metabolism)</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps monoclonaux</term>
<term>Antigènes de différenciation des lymphocytes T (métabolisme)</term>
<term>Facteur thymique sérique (métabolisme)</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Gestation animale (immunologie)</term>
<term>Grossesse</term>
<term>Immunohistochimie</term>
<term>Souris</term>
<term>Thymus (glande) (anatomie et histologie)</term>
<term>Thymus (glande) (immunologie)</term>
<term>Thymus (glande) (métabolisme)</term>
<term>Épithélium (anatomie et histologie)</term>
<term>Épithélium (immunologie)</term>
<term>Épithélium (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, Differentiation, T-Lymphocyte</term>
<term>Thymic Factor, Circulating</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Monoclonal</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomie et histologie" xml:lang="fr"><term>Thymus (glande)</term>
<term>Épithélium</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Epithelium</term>
<term>Thymus Gland</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Gestation animale</term>
<term>Thymus (glande)</term>
<term>Épithélium</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Epithelium</term>
<term>Pregnancy, Animal</term>
<term>Thymus Gland</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Epithelium</term>
<term>Thymus Gland</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes de différenciation des lymphocytes T</term>
<term>Facteur thymique sérique</term>
<term>Thymus (glande)</term>
<term>Épithélium</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Immunohistochemistry</term>
<term>Mice</term>
<term>Pregnancy</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Anticorps monoclonaux</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Immunohistochimie</term>
<term>Souris</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Changes in the murine thymus during pregnancy were studied using immunocytochemistry with monoclonal antibodies against thymic epithelial, neuroendocrine, and thymulin-producing cells, fibroblasts, blood vessels and connective tissue components. Extensive alterations occur in mid-pregnancy. The medulla was greatly enlarged in the involuted thymus, and there were greater numbers of epithelial cells. These epithelial cells had an altered distribution forming large structures surrounding spherical masses of mononuclear cells, lacked epithelial cells and often contained a central blood vessel with fibroblasts and connective tissue. We have called these structures 'medullary epithelial rings' (MERs). To our knowledge these structures have not been described before. Late in pregnancy the loss of the central mononuclear cells leaves collapsed structures in a smaller medulla that nevertheless retains many epithelial cells. In virgins and early-pregnancy, there are cortical channels free of epithelial cells that are very infrequent later in pregnancy. This may reflect the loss of steroid-sensitive thymocytes from the cortex. The influence of sex-steroids, neurological impulses and immune activity in causing the changes are discussed, as are the possible consequences in pregnancy of a reduced, thymocyte-depleted cortex and an enlarged medulla that shows great complexity and activity.</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Nottinghamshire</li>
</region>
<settlement><li>Nottingham</li>
</settlement>
<orgName><li>Université de Nottingham</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Gil, A L" sort="Gil, A L" uniqKey="Gil A" first="A L" last="Gil">A L Gil</name>
<name sortKey="Kendall, M D" sort="Kendall, M D" uniqKey="Kendall M" first="M D" last="Kendall">M D Kendall</name>
</noCountry>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Clarke, A G" sort="Clarke, A G" uniqKey="Clarke A" first="A G" last="Clarke">A G Clarke</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004260 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004260 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:8111839 |texte= The effects of pregnancy on the mouse thymic epithelium. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:8111839" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
This area was generated with Dilib version V0.6.33. |